Prolotherapy may help in the following conditions: low back pain, tendinitis and osteoarthritis. The evidence for these uses, however, is tentative.There is also little good evidence for sports related injuries.
While no formal practice guidelines have been published, prolotherapy treatment commonly consists of several injection sessions delivered every 2 to 6 weeks over the course of several months. During an individual prolotherapy session, therapeutic solutions are injected at sites of painful and tender ligament and tendon insertions, and in adjacent joint spaces. Injected solutions (“proliferants”) have historically been hypothesized to cause local irritation, with subsequent inflammation and tissue healing, resulting in enlargement and strengthening of damaged ligamentous, tendon and intra-articular structures. These processes were thought to improve joint stability, biomechanics, function and ultimately, to decrease pain.